Severe tardive dystonia: Treatment with continuous intrathecal baclofen administration
Identifieur interne : 005263 ( Main/Exploration ); précédent : 005262; suivant : 005264Severe tardive dystonia: Treatment with continuous intrathecal baclofen administration
Auteurs : Dressler [Allemagne] ; Remt-Otto Oeljeschl Ger [Allemagne] ; Eckart Rüther [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-07.
English descriptors
- KwdEn :
- Antipsychotic Agents (adverse effects), Baclofen (administration & dosage), Baclofen (therapeutic use), Blood-Brain Barrier, Continuous intrathecal baclofen, Drug Resistance, Dystonia (chemically induced), Dystonia (drug therapy), Female, GABA Agonists (administration & dosage), GABA Agonists (therapeutic use), Humans, Implantable pump system, Infusion Pumps, Implantable, Injections, Spinal, Middle Aged, Severe tardive axial dystonia.
- MESH :
- chemical , administration & dosage : Baclofen, GABA Agonists.
- chemical , adverse effects : Antipsychotic Agents.
- chemical , therapeutic use : Baclofen, GABA Agonists.
- chemically induced : Dystonia.
- drug therapy : Dystonia.
- Blood-Brain Barrier, Drug Resistance, Female, Humans, Infusion Pumps, Implantable, Injections, Spinal, Middle Aged.
Abstract
Treatment of tardive dystonia with oral baclofen produces ambivalent and overall disappointing results. However, because only a small proportion of the baclofen penetrates into the central nervous system when administered orally, we tested whether it is possible to increase the efficacy of treatment by continuous intrathecal infusion of baclofen (CITB) in a patient with severe tardive axial dystonia unresponsive to conventional therapy. A dose of 100 m̈g/day improved muscle tone, head control, posture, and walking distance; electromyography showed a marked decrease of dystonic muscle activity with fully preserved voluntary muscle activity, and the patient reported substantial reduction of pain. Apart from some minor discomfort at the site of operation, no side effects were noted. Further studies should be encouraged to evaluate the usefulness of CITB for other patients with severe and otherwise untreatable tardive dystonia.
Url:
DOI: 10.1002/mds.870120416
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-07">1997-07</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="585">585</biblScope><biblScope unit="page" to="587">587</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B4194A17F27D189F04B259722BA24CF44FB85BB4</idno><idno type="DOI">10.1002/mds.870120416</idno><idno type="ArticleID">MDS870120416</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antipsychotic Agents (adverse effects)</term><term>Baclofen (administration & dosage)</term><term>Baclofen (therapeutic use)</term><term>Blood-Brain Barrier</term><term>Continuous intrathecal baclofen</term><term>Drug Resistance</term><term>Dystonia (chemically induced)</term><term>Dystonia (drug therapy)</term><term>Female</term><term>GABA Agonists (administration & dosage)</term><term>GABA Agonists (therapeutic use)</term><term>Humans</term><term>Implantable pump system</term><term>Infusion Pumps, Implantable</term><term>Injections, Spinal</term><term>Middle Aged</term><term>Severe tardive axial dystonia</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Baclofen</term><term>GABA Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Baclofen</term><term>GABA Agonists</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Blood-Brain Barrier</term><term>Drug Resistance</term><term>Female</term><term>Humans</term><term>Infusion Pumps, Implantable</term><term>Injections, Spinal</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Treatment of tardive dystonia with oral baclofen produces ambivalent and overall disappointing results. However, because only a small proportion of the baclofen penetrates into the central nervous system when administered orally, we tested whether it is possible to increase the efficacy of treatment by continuous intrathecal infusion of baclofen (CITB) in a patient with severe tardive axial dystonia unresponsive to conventional therapy. A dose of 100 m̈g/day improved muscle tone, head control, posture, and walking distance; electromyography showed a marked decrease of dystonic muscle activity with fully preserved voluntary muscle activity, and the patient reported substantial reduction of pain. Apart from some minor discomfort at the site of operation, no side effects were noted. Further studies should be encouraged to evaluate the usefulness of CITB for other patients with severe and otherwise untreatable tardive dystonia.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Basse-Saxe</li></region><settlement><li>Göttingen</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Dressler" sort="Dressler" uniqKey="Dressler" last="Dressler">Dressler</name></region><name sortKey="Oeljeschl Ger, Remt Tto" sort="Oeljeschl Ger, Remt Tto" uniqKey="Oeljeschl Ger R" first="Remt-Otto" last="Oeljeschl Ger">Remt-Otto Oeljeschl Ger</name><name sortKey="Ruther, Eckart" sort="Ruther, Eckart" uniqKey="Ruther E" first="Eckart" last="Rüther">Eckart Rüther</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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